Publications
2023
Friedrich J. Ehinger, Sarah P. Niehs, Benjamin Dose, Maria Dell, Jana Krabbe, Sacha J. Pidot, Timothy P. Stinear, Kirstin Scherlach, Claudia Ross, Gerald Lackner, Christian Hertweck: Analysis of rhizonin biosynthesis reveals origin of pharmacophoric furylalanine moieties in diverse cyclopeptides. In: Angewandte Chemie International Edition, 62 (2023). - .
doi:10.1002/anie.202308540
Nikolai A. Löhr, Malik Rakhmanov, Jacob M. Wurlitzer, Gerald Lackner, Markus Gressler, Dirk Hoffmeister: Basidiomycete non-reducing polyketide synthases function independently of SAT domains. In: Fungal Biology and Biotechnology, 10 (2023). - .
doi:10.1186/s40694-023-00164-z
2022
Mahmudul Hasan, Sabrina Schulze, Leona Berndt, Gottfried J. Palm, Daniel Braga, Ingrid Richter, Daniel Last, Michael Lammers, Gerald Lackner: Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F₄₂₀ and its derivative 3PG-F₄₂₀. In: mBio, 13 (2022). - .
doi:10.1128/mbio.03501-21
Daniel Last, Mahmudul Hasan, Linda Rothenburger, Daniel Braga, Gerald Lackner: High-yield production of coenzyme F₄₂₀ in Escherichia coli by fluorescence-based screening of multi-dimensional gene expression space. In: Metabolic Engineering, 73 (2022). - S. 158-167.
doi:10.1016/j.ymben.2022.07.006
Mark Ellerhorst, Stefanie A. Barth, Ana Patrícia Graça, Walid K. Al-Jammal, Luis Peña-Ortiz, Ivan Vilotijevic, Gerald Lackner: S-Adenosylmethionine (SAM)-dependent methyltransferase MftM is responsible for methylation of the redox cofactor mycofactocin. In: ACS Chemical Biology, 17 (2022). - S. 3207-3217.
doi:10.1021/acschembio.2c00659
Gerald Lackner: Webb, Amy ; Hessel, Andrew: The Genesis Machine: our quest to rewrite life in the age of synthetic biology. New York, 2022. In:BIOspektrum, 28, S. 769: 2022
doi:10.1007/s12268-022-1867-6
2021
Soohyun Um, Huijuan Guo, Sirinthra Thiengmag, René Benndorf, Robert Murphy, Maja Rischer, Daniel Braga, Michael Poulsen, Z. Wilhelm de Beer, Gerald Lackner, Christine Beemelmanns: Comparative genomic and metabolic analysis of Streptomyces sp. RB110 morphotypes illuminates genomic rearrangements and formation of a new 46-membered antimicrobial macrolide. In: ACS Chemical Biology, 16 (2021). - S. 1482-1492.
doi:10.1021/acschembio.1c00357
2020
Luis Peña-Ortiz, Ana Patrícia Graça, Huijuan Guo, Daniel Braga, Tobias G. Köllner, Lars Regestein, Christine Beemelmanns, Gerald Lackner: Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF. In: Chemical Science, 11 (2020). - S. 5182-5190.
doi:10.1039/D0SC01172J
Luis Peña-Ortiz, Ivan Schlembach, Gerald Lackner, Lars Regestein: Impact of oxygen supply and scale up on Mycobacterium smegmatis cultivation and mycofactocin formation. In: Frontiers in Bioengineering and Biotechnology, 8 (2020). - .
doi:10.3389/fbioe.2020.593781
Claudius Lenz, Jonas Wick, Daniel Braga, María García‐Altares, Gerald Lackner, Christian Hertweck, Markus Gressler, Dirk Hoffmeister: Injury‐triggered blueing reactions of Psilocybe “magic” mushrooms. In: Angewandte Chemie International Edition, 59 (2020). - S. 1450-1454.
doi:10.1002/anie.201910175
Daniel Braga, Mahmudul Hasan, Tabea Kröber, Daniel Last, Gerald Lackner: Redox coenzyme F₄₂₀ biosynthesis in Thermomicrobia involves reduction by stand-alone nitroreductase superfamily enzymes. In: Applied and Environmental Microbiology, 86 (2020). - .
doi:10.1128/AEM.00457-20
2019
Martina Stöckli, Brandon I. Morinaka, Gerald Lackner, Anja Kombrink, Ramon Sieber, Céline Margot, Claire E. Stanley, Andrew J. deMello, Jörn Piel, Markus Künzler: Bacteria‐induced production of the antibacterial sesquiterpene lagopodin B in Coprinopsis cinerea. In: Molecular Microbiology, 112 (2019). - S. 605-619.
doi:10.1111/mmi.14277
Daniel Braga, Daniel Last, Mahmudul Hasan, Huijuan Guo, Daniel Leichnitz, Zerrin Uzum, Ingrid Richter, Felix Schalk, Christine Beemelmanns, Christian Hertweck, Gerald Lackner: Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F₄₂₀. In: ACS Chemical Biology, 14 (2019). - S. 2088-2094.
doi:10.1021/acschembio.9b00605
Sebastian Götze, Johannes Arp, Gerald Lackner, Shuaibing Zhang, Hajo Kries, Martin Klapper, María García-Altares, Karsten Willing, Markus Günther, Pierre Stallforth: Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases. In: Chemical Science, 10 (2019). - S. 10979-10990.
doi:10.1039/C9SC03633D
2018
Martin Klapper, Daniel Braga, Gerald Lackner, Rosa Herbst, Pierre Stallforth: Bacterial alkaloid biosynthesis: structural diversity via a minimalistic nonribosomal peptide synthetase. In: Cell Chemical Biology, 25 (2018). - S. 659-665.e9.
doi:10.1016/j.chembiol.2018.02.013
Eileen Brandenburger, Daniel Braga, Anja Kombrink, Gerald Lackner, Julia Gressler, Markus Künzler, Dirk Hoffmeister: Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases. In: Fungal Genetics and Biology, 112 (2018). - S. 55-63.
doi:10.1016/j.fgb.2016.07.008
Huijuan Guo, Alexander Schmidt, Philipp Stephan, Luka Raguž, Daniel Braga, Marcel Kaiser, Hans‐Martin Dahse, Christiane Weigel, Gerald Lackner, Christine Beemelmanns: Precursor‐directed diversification of cyclic tetrapeptidic pseudoxylallemycins. In: ChemBioChem, 19 (2018). - S. 2307-2311.
doi:10.1002/cbic.201800503
2017
Eileen Brandenburger, Markus Gressler, Robin Leonhardt, Gerald Lackner, Andreas Habel, Christian Hertweck, Matthias Brock, Dirk Hoffmeister: A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. In: Applied and Environmental Microbiology, 83 (2017). - .
doi:10.1128/AEM.01478-17
Gerald Lackner, Eike Edzard Peters, Eric J. N. Helfrich, Jörn Piel: Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges. In: Proceedings of the National Academy of Sciences of the United States of America, 114 (2017). - S. E347-E356.
doi:10.1073/pnas.1616234114
Daniel Braga, Gerald Lackner: One ring to fight them all: the sulfazecin story. In: Cell Chemical Biology, 24 (2017). - S. 1-2.
doi:10.1016/j.chembiol.2017.01.001
2016
Firoz Shah, César Nicolás, Johan Bentzer, Magnus Ellström, Mark Smits, Francois Rineau, Björn Canbäck, Dimitrios Floudas, Robert Carleer, Gerald Lackner, Jana Braesel, Dirk Hoffmeister, Bernard Henrissat, Dag Ahrén, Tomas Johansson, David S. Hibbett, Francis Martin, Per Persson, Anders Tunlid: Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors. In: New Phytologist, 209 (2016). - S. 1705-1719.
doi:10.1111/nph.13722
Jonas Wick, Daniel Heine, Gerald Lackner, Mathias Misiek, James Tauber, Hans Jagusch, Christian Hertweck, Dirk Hoffmeister: A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (Honey Mushroom) toxins. In: Applied and Environmental Microbiology, 82 (2016). - S. 1196-1204.
doi:10.1128/AEM.03168-15
Sebastian W. Fuchs, Gerald Lackner, Brandon I. Morinaka, Yohei Morishita, Teigo Asai, Sereina Riniker, Jörn Piel: A lanthipeptide‐like N‐terminal leader region guides peptide epimerization by Radical SAM epimerases: implications for RiPP evolution. In: Angewandte Chemie International Edition, 55 (2016). - S. 12330-12333.
doi:10.1002/anie.201602863
2015
Daniel Kalb, Gerald Lackner, Marcus Rappe, Dirk Hoffmeister: Activity of α‐aminoadipate reductase depends on the N‐terminally extending domain. In: ChemBioChem, 16 (2015). - S. 1426-1430.
doi:10.1002/cbic.201500190
Daniel Kalb, Thorsten Heinekamp, Gerald Lackner, Daniel H. Scharf, Hans-Martin Dahse, Axel A. Brakhage, Dirk Hoffmeister: Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. In: Applied and Environmental Microbiology, 81 (2015). - S. 1594-1600.
doi:10.1128/AEM.03268-14
Katharina Graupner, Gerald Lackner, Christian Hertweck: Genome sequence of mushroom soft-rot pathogen Janthinobacterium agaricidamnosum. In: Genome Announcements, 3 (2015). - .
doi:10.1128/genomeA.00277-15
Magnus Karlsson, Mikael Brandström Durling, Jaeyoung Choi, Chatchai Kosawang, Gerald Lackner, Georgios D. Tzelepis, Kristiina Nygren, Mukesh K. Dubey, Nathalie Kamou, Anthony Levasseur, Antonio Zapparata, Jinhui Wang, Daniel Buchvaldt Amby, Birgit Jensen, Sabrina Sarrocco, Emmanuel Panteris, Anastasia L. Lagopodi, Stefanie Pöggeler, Giovanni Vannacci, David B. Collinge, Dirk Hoffmeister, Bernard Henrissat, Yong-Hwan Lee, Dan Funck Jensen: Insights on the evolution of mycoparasitism from the genome of Clonostachys rosea. In: Genome Biology and Evolution, 7 (2015). - S. 465-480.
doi:10.1093/gbe/evu292
Zerrin Uzum, Alba Silipo, Gerald Lackner, Antonia De Felice, Antonio Molinaro, Christian Hertweck: Structure, genetics and function of an exopolysaccharide produced by a bacterium living within fungal hyphae. In: ChemBioChem, 16 (2015). - S. 387-392.
doi:10.1002/cbic.201402488
2014
Nadine Moebius, Zerrin Üzüm, Jan Dijksterhuis, Gerald Lackner, Christian Hertweck: Active invasion of bacteria into living fungal cells. In: eLife, 3 (2014). - .
doi:10.7554/eLife.03007
Chiaki Hori, Takuya Ishida, Kiyohiko Igarashi, Masahiro Samejima, Hitoshi Suzuki, Emma Master, Patricia Ferreira, Francisco J. Ruiz-Dueñas, Benjamin Held, Paulo Canessa, Luis F. Larrondo, Monika Schmoll, Irina S. Druzhinina, Christian P. Kubicek, Jill A. Gaskell, Phil Kersten, Franz St. John, Jeremy Glasner, Grzegorz Sabat, Sandra Splinter BonDurant, Khajamohiddin Syed, Jagjit Yadav, Anthony C. Mgbeahuruike, Andriy Kovalchuk, Fred O. Asiegbu, Gerald Lackner, Dirk Hoffmeister, Jorge Rencoret, Ana Gutiérrez, Hui Sun, Erika Lindquist, Kerrie Barry, Robert Riley, Igor V. Grigoriev, Bernard Henrissat, Ursula Kües, Randy M. Berka, Angel T. Martínez, Sarah F. Covert, Robert A. Blanchette, Daniel Cullen: Analysis of the Phlebiopsis gigantea genome, transcriptome and secretome provides insight into its pioneer colonization strategies of wood. In: PLoS Genetics, 10 (2014). - .
doi:10.1371/journal.pgen.1004759
Pranatchareeya Chankhamjon, Daniela Boettger-Schmidt, Kirstin Scherlach, Barbara Urbansky, Gerald Lackner, Daniel Kalb, Hans-Martin Dahse, Dirk Hoffmeister, Christian Hertweck: Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. In: Angewandte Chemie International Edition, 53 (2014). - S. 13409-13413.
doi:10.1002/anie.201407624
Daniel Kalb, Gerald Lackner, Dirk Hoffmeister: Functional and phylogenetic divergence of fungal adenylate-forming reductases. In: Applied and Environmental Microbiology, 80 (2014). - S. 6175-6183.
doi:10.1128/AEM.01767-14
2013
Gerald Lackner, Markus Bohnert, Jonas Wick, Dirk Hoffmeister: Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity. In: Chemistry & Biology, 20 (2013). - S. 1101-1106.
doi:10.1016/j.chembiol.2013.07.009
Wieland Steinchen, Gerald Lackner, Sabiha Yasmin, Markus Schrettl, Hans-Martin Dahse, Hubertus Haas, Dirk Hoffmeister: Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen aspergillus fumigatus. In: Applied and Environmental Microbiology, 79 (2013). - S. 6670-6676.
doi:10.1128/AEM.02642-13
Kirstin Scherlach, Gerald Lackner, Katharina Graupner, Sacha Pidot, Tom Bretschneider, Christian Hertweck: Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. In: ChemBioChem, 14 (2013). - S. 2439-2443.
doi:10.1002/cbic.201300553
Daniel Kalb, Gerald Lackner, Dirk Hoffmeister: Fungal peptide synthetases: an update on functions and specificity signatures. In: Fungal Biology Reviews, 27 (2013). - S. 43-50.
doi:10.1016/j.fbr.2013.05.002
2012
Barbara Wackler, Gerald Lackner, Yit Heng Chooi, Dirk Hoffmeister: Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α‐keto acids. In: ChemBioChem, 13 (2012). - S. 1798-1804.
doi:10.1002/cbic.201200187
Gerald Lackner, Mathias Misiek, Jana Braesel, Dirk Hoffmeister: Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases. In: Fungal Genetics and Biology, 49 (2012). - S. 996-1003.
doi:10.1016/j.fgb.2012.09.009
Katharina Graupner, Kirstin Scherlach, Tom Bretschneider, Gerald Lackner, Martin Roth, Harald Gross, Christian Hertweck: Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. In: Angewandte Chemie International Edition, 51 (2012). - S. 13173-13177.
doi:10.1002/anie.201206658
Tom Bretschneider, Katharina Graupner, Christian Hertweck, Gerald Lackner, Kirstin Scherlach: Jagaricin, derivatives, and uses thereof
EP2703410A1, (2012)
Alba Silipo, Maria R. Leone, Rosa Lanzetta, Michelangelo Parrilli, Gerald Lackner, Benjamin Busch, Christian Hertweck, Antonio Molinaro: Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4). In: Carbohydrate Research, 347 (2012). - S. 95-98.
doi:10.1016/j.carres.2011.10.038
Kirstin Scherlach, Benjamin Busch, Gerald Lackner, Uta Paszkowski, Christian Hertweck: Symbiotic cooperation in the biosynthesis of a phytotoxin. In: Angewandte Chemie International Edition, 51 (2012). - S. 9615-9618.
doi:10.1002/anie.201204540
2011
Jay E. Gee, Mindy B. Glass, Gerald Lackner, Leta O. Helsel, Maryam Daneshvar, Dannie G. Hollis, Jean Jordan, Roger Morey, Arnold Steigerwalt, Christian Hertweck: Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. In: PLoS One, 6 (2011). - .
doi:10.1371/journal.pone.0015731
Gerald Lackner, Nadine Moebius, Laila Partida-Martinez, Christian Hertweck: Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus. In: Journal of Bacteriology, 193 (2011). - S. 783-784.
doi:10.1128/JB.01318-10
Gerald Lackner, Nadine Moebius, Christian Hertweck: Endofungal bacterium controls its host by an hrp type III secretion system. In: The ISME Journal, 5 (2011). - S. 252-261.
doi:10.1038/ismej.2010.126
Gerald Lackner, Nadine Moebius, Laila P. Partida-Martinez, Sebastian Boland, Christian Hertweck: Evolution of an endofungal lifestyle: deductions from the Burkholderia rhizoxinica genome. In: BMC Genomics, 12 (2011). - .
doi:10.1186/1471-2164-12-210
Gerald Lackner, Christian Hertweck: Impact of endofungal bacteria on infection biology, food safety, and drug development. In: PLoS Pathogens, 7 (2011). - .
doi:10.1371/journal.ppat.1002096
2010
Maria R. Leone, Gerald Lackner, Alba Silipo, Rosa Lanzetta, Antonio Molinaro, Christian Hertweck: An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin‐producing bacteria in their fungal host. In: Angewandte Chemie International Edition, 49 (2010). - S. 7476-7480.
doi:10.1002/anie.201003301
2009
Gerald Lackner, Laila P. Partida-Martinez, Christian Hertweck: Endofungal bacteria as producers of mycotoxins. In: Trends in Microbiology, 17 (2009). - S. 570-576.
doi:10.1016/j.tim.2009.09.003
Gerald Lackner, Nadine Möbius, Kirstin Scherlach, Laila P. Partida-Martinez, Robert Winkler, Imke Schmitt, Christian Hertweck: Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. In: Applied and Environmental Microbiology, 75 (2009). - S. 2982-2986.
doi:10.1128/AEM.01765-08
2007
Gerald Lackner, Angéla Schenk, Zhongli Xu, Kathrin Reinhardt, Zeynep S. Yunt, Jörn Piel, Christian Hertweck: Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. In: Journal of the American Chemical Society, 129 (2007). - S. 9306-9312.
doi:10.1021/ja0718624