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Biochemistry of Microorganisms | Prof. Dr. Gerald Lackner

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New publication "Pilot Scale Production of a F₄₂₀ Precursor Under Microaerobic Conditions"

23 April 2025

Supported by Prof. Dr. Gerald Lackner a research article was published on the development of an overall process workflow to obtain pure F-O from an engineered Escherichia coli host strain. We were able to shift the cofactor synthesis from riboflavin to F-O via the implementation of oxygen-limited process conditions during heterologous fbiC expression and reached a final titer of 5.05 mg L-1 F-O in our fermentation broth, which for the first time allows the purification of relevant amounts for subsequent experiments.

Thank you to everybody involved in this great achievement!

Link zum Artikel im Biotechnology Journal

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